HIV Replication Lecture: In a Becky way!!

At dahil karamihan sa mga biktima ng HIV ay ang mga becklings, I am willing to educate them about HIV in a becky way as laboratory/pre-pathology med student, myself. CHICA! Gusto ko din mag avail ng becky language in teaching science para hindi monotonous ang peg. BONGGA! Try ko din kaya mag-avail nito in teaching mathematics! haha!!

try natin ang tagalog in teaching math:

ang ekis ay katumbas sa negatibong ‘ba’ dagdag o kaltas sa parisukat ugat ng pinarisukatan na ‘ba’ na kinaltasan ng apat na ‘a’ at ‘ca’ sa ibabaw ng dalawa at ‘a’

HAHAHA!! KALOKA! Guess anong formula yan. haha!

Far out na tayo, let’s continue!

Ang HIV replication ay isang hagdan-hagdang palayan. Maraming steps! Kaya peg natin dito is to learn each step.

Step 1: Fusion of HIV Cell to the Host Cell.

Just like the sperm and egg cell na mag unite or you know na, ganito din ang peg ng HIV virus. Fuse siya sa host cell ng ating body na specifically yung T-Lymphocyte natin. May receptors ang HIV na tinatawag na GP120 na peg nyang mag bind sa receptors ng T-lymphocyte na tinatawag na CD4+. At dahil dyan, bind na cla.

Step 2: HIV enters the host cell at maghagsik ng lagim!

Nagmukha na ngang alien tong HIV na to, confident pang maghagsik ng lagim! Totoo yan, as the viral particle and host cell binds, the viral particle enters the host cell at maghahagsik ng lagim.  Ang pinaka mastermind nyang ibubuga ay ang RNA. Dito din siya magre-release ng 3 replication essential enzymes for the HIV to replicate. Ito ay ang mga PROTEASE, INTEGRASE, and REVERSE TRANSCRIPTASE. Hindi lang ang mga yan, release din sila ng other viral proteins.

Step 3: Viral DNA is formed by reverse transcription. TAKE NOTE, DNA!!

Nakakaloka kaya yan! Take note, HIV’s building block is RNA, hindi DNA pero may kapangyarihan siyang mag change into DNA! Tarush! Magic kariton kaya gamit nito?! Choz! Kaya nyang mag change ng building block because of the REVERSE TRANSCRIPTASE enzyme. Siya lang ang may kayang mag change ng RNA to DNA. 

Step 4: Viral DNA is transported across the nucleus and integrates into the host DNA. 

Nakakaloka ang part na ‘to! Pramis! Gumanda na nga ang viral particle dahil transform na siya into DNA, confident pang mag travel across the nucleus! Ganda nya lang!! Peg kasi niya dito is mangengechos sa host DNA. pakialamera talaga! Dito na yung process na mag integrates siya into the T-lymphocyte’s DNA through INTEGRASE. Sumasanib na siya sa ating DNA para maging evil at mag command to make more HIV minions!

Step 5: New viral RNA is used as genomic RNA and to make viral proteins!

At dahil evil na yung DNA ng T-lymphocyte natin, may kapangyarihan itong mag command to synthesize RNA particles! Gamit ito to make more viral proteins. Kakainis!!

Step 6: New viral RNA and proteins move to cell surface and a new, mature, HIV forms.

Kita nyo na?! Lilipad na ang mga demonyong to sa ibabaw ng T-lymphocyte cell para makalabas. The new viral RNA and other viral proteins ay ang core materials for replication so kailangan nila ng covering or envelope. Chica! Trench coat peg din nito, ha! Steal sila ng covering from the cell surface ng T-lymphocyte dahil di nila afford (choz!) at lalabas na from their sinisiraan!

Step 7: The virus matures by PROTEASE releasing individual HIV proteins. 

Yun nga, magtatanda din si lola pero mas nakakaloka dahil maging mas malakas siya. After that, trip to Jerusalem na cya to infect other T-lymphocyte cell. Ito yung dahil kung bakit paunti-unti ang CD4+ count ng HIV positive patient. Echosera talaga tong alien to.

HIV

Scary di ba? Kaya if di nyo mapigilan mga shonty at alindog nyo, gamit kayo ng condom! This is for your own protection.

Ang hirap mag becky language! haha!! To learn more about protective sex and how to get yourself protected from HIV, watch nyo tong video na to. Believe me, avail nyo na to kasi gandang lalaki ang magtuturo sa inyo kung paano. Boyfriend ko. CHOZ!!!! HAHA!

http://www.youtube.com/watch?v=-Xak0Q_IY5E

Follow nyo na din ang LoveYourself on Twitter: @LoveYourself_VA

KNOW YOUR STATUS. GET TESTED! WAG KA NANG PATUMPIK-TUMPIK PA! BOOM KARAKARAKA!!

Always,

   B

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Med Life: Think of your specialty!

Hearing kids saying that they want to become medical doctors someday really softens my heart. I’ve been dreaming to become a medical doctor since I was a kid. Well actually, I once dreamed on getting a chemistry degree but my heart told me to choose the medical career. Chemistry is fun and cool which kids usually think of mad scientists hysterically mixing explosive substances or concoctions or whatever… but my heart keeps telling me to choose a med-related undergraduate. I followed what my heart told me and currently taking up Clinical Laboratory Science at Silliman University Institute of Clinical Laboratory Sciences. To make it clearer, I’m taking up Laboratory Medicine and Basic Pathology. I now already achieved a part of my dream but it’s still not the endpoint to stop my medical career. The foremost goal of my dream is to get a specialty.

Teka lang. Notice nyo? English peg ko ngayon! Chos!

Thinking of a specialty you’re planning to grab is not easy. You really have to put your heart on a specific field na keri-keri at love mo. Hindi yan pilit-pilit na lang kasi yan gusto parents mo. Do you expect to become a better doctor in such field you’re taking up even you don’t like? Nasa sa ‘yo ang kasagutan, if kaya mo then PUSH mo! chos. In my case, it’s not my peg.

Dahil sa ka echosera ko before na feel to the highest level na ang ambition, I was caught in confusion sa Cardiology, Neurology, Pathology, Pediatrics, and even Obstetrics and Gynecology. (nobody cares…. hahaha! walang hiya. ganda nyo lang! haha)

I changed my mind on not pursuing Cardiology kasi I can’t withstand Cardiac System in our Anatomy Class! ang hirap kaya ng heart akala ‘nyo easy lang. pag-ibig lang kasi alam ‘nyo. CHAROT! Neurology? don’t think about it. baka utak ko mismo ang masira haha! How about Ob/Gyne? Di ko peg yan. Mga notches gusto ko. CHOS!! Pero seryoso, maganda din kaya Obstetrics and Gynecology pero di ko lang talaga peg.

Dumating na ang inaabangan kong desisyon sa buhay (chos). I go for Internal Medicine with Infectious Diseases as my subspecialty. (sa dami-daming ka echosan, nandyan lang pala yan. haha!)

As for my advice to those who are planning to take up Pre-Med & Med, plan ahead of your specialty that best suites you. Make sure it’s the right field your heart tells you. If it is your best choice, wag ka nang patumpik-tumpik pa! BOMKARAKARAKA!

Love,

B

TIPS FOR INCOMING SILLIMAN UNIVERSITY MEDTECH FRESHMEN:

Clinical Laboratory Science or Medical Technology is a branch of laboratory medicine dealing with the examination of the body fluids and tissues with the use of various chemical, microscopic and bacteriological methods. Sounds complicated, right? Here are some of my tips to survive the beginning of your journey:

  • Get rid of blood and needle phobia. If you’re too lucky to get MT13 for the first semester, then brace yourself. MT13 is more on Phlebotomy where you have to grab a lab partner and start withdrawing blood with each other. Believe it or not, most of us, even us the upper class, are afraid of needles but we have to get rid of that stereotype because you might be probably wondering why your name is on the ‘advised to shift’ list.
  • Don’t pressure yourself. It is expected that Clinical Laboratory Science is a tough field. Most of the professors especially from biological sciences are feared since they will really put you in an autoclave-like (high pressure and high temperature) pre-med life. Time management is the only key to overcome the stress. The only thing you have to do is to start your tasks ahead of time and do advanced study if you have free-time but be sure to have time for leisure and relaxation as well. MANAGE YOUR TIME PROPERLY.
  • Be patient. Medical Technology will really tempt you to become ill-tempered especially when you’re stressing yourself too much on paperwork. Keep in mind that the foremost attitude of a medical technologist is being patient. Do you expect to pass MedTech and do laboratory tests well in the future if you, yourself can’t even show patience to your paperwork and homeworks? NO. So, keep smiling to have dimples instead of having wrinkles. It’s the best way to exercise your zygomaticus muscle too 🙂
  • Be kind and respectful to our department especially in Biological Science department. You’ll find out that soon. LOL!

Just love your Pre-Med life and have fun! We also have exciting activities prepared by the Medical Technology Society Officers to show that we just don’t stay inside the laboratory performing complicated laboratory tests and befriend microorganisms but we also need leisure too, you know. haha. Good luck! 🙂